Immune Response to Third and Fourth COVID-19 Vaccination in Hemodialysis Patients and Kidney Transplant Recipients

Immune Response to Third and Fourth COVID-19 Vaccination in Hemodialysis Patients and Kidney Transplant Recipients

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Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is a serious hazard for hemodialysis (HD) patients and kidney transplant (KTX) recipients as they suffer from an impaired immune response to SARS-CoV-2 vaccination.In addition, a definition of SARS-CoV-2 IgG titer that indicates a sufficient immune response, especially against new omicron variants, is urgently needed.In the present study, the immune response to either read more a third or a fourth dose of a mRNA vaccine was investigated in 309 dialysis and 36 KTX patients.SARS-CoV-2 IgG titer thresholds indicating neutralizing activity against wild type (WT) and the omicron variant BA.

1 were quantified.After four vaccine doses, a high-neutralizing activity against WT was evidenced in HD patients, whereas the neutralizing rate natio glide on eyeshadow stick against BA.1 was significant lower.Concerning KTX recipients, humoral and cellular immune responses after a third vaccination were still highly impaired.

This calls for modified omicron-targeting vaccines.